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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'aeb8c5f404117e35684042b053721e9c8762e9fad27c5180e1dce31a1dca4a06' 
  AND token = 'FU3puKxxultkS+G0kyJeongGbofpuY04qx1qffAZpQ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}