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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a3aac0ab669b331669c779d13c9017e7d39fd846e15a18f2c03e4ca2b9dc0219' 
  AND token = '+5Sk/BU/YJkot08gRzE8khrVKsLMlXcMoRk9NUMiAkA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}