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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a72de3340ae42090cca801a00743a1380d0f3ab518f1889362769f375563b389' 
  AND token = 'n7+GdG50dEhGjHvSCWMGonY1nyBFzn8lRC+mgSVE4Gc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00053

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}