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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42eb12c16e4dcdeec57f7f338067ad2d5a3e9a1822bd62aff19a12c8438f7243' 
  AND token = 'UMdcJWJ9qEPEC0FfVKHDPkY68zlHVJRpdmZU5YlTeNc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}