SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b7f57472e87e81805c9039c4e01306a280d1475184fc3a437eb854fae3b1201' 
  AND token = 'VPmEyDOFxD3+1Utbrqe0LzFvbf84g3NxSQKjxMn3nCk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00038

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}