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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ab2b2cc6194f2c54dccff0cbd02587e0d6fc46aff0c61613bfb364b71a906be' 
  AND token = 'VzI6UEC+DsuhqCe4b6AFEsneAEfJYu+MVWf1X0YxDbk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}