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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e6158ec51afd6109cb7ee21449862a72ee78cade6dd5d7a4e4150a8828c68282' 
  AND token = 'GrcTz2aUgJCrluFr0p20Upm9HCeLukOLSbwyEgs6t4s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}