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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2fe467233ca5078a3713bdb9b5f0c4a1553bc663dbbe65cab9270c452c31cef7' 
  AND token = 'gWAlStA/a8PJV/BSebwFFSq4VWACDZeIWPZexeLT3hI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}