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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80a201335a757d2cb498f397c7967eef9586073191eada7cc19ad836d85e5c45' 
  AND token = 'vAtaNEZWPaHh2XvRbuwDehTYcJDdcih5uWeRCBmB4Ow=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00056

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}