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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a4ffa04ef46c375f3d3019539ea74e539a5050b5767e6fdafde53c4416e31a16' 
  AND token = '3cCTx8B9kWJq5UE+HA9+xP/+sLX1ID2MJJUCXoK+vTk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}