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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '448ed18330d291be0f5f2be325a5d4db4f4c84dc8cb02eacdd0a223d538f463d' 
  AND token = 'GIUXBqnlOKtfV2wSDc4S5d+3vTnFJhvc6PUYgVY0TFE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00040

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}