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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '789110e9a524e7b25366502e06c375482da855385f724e4f450e6227f8cccdf0' 
  AND token = 'I2zcgK3EAOfNUNN6XQvZeFtQxaomRkPAyOr/hFEObY0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}