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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33346a81263cca8a49163e75a917db7381546793c35a6806465cc441502c0661' 
  AND token = 'qVFX6oZN1PHR0mYqHeDyQKF5R0AOtdGbZcOqI2jKKEU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}