SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd749393543b3065ae19ab0a65793e45a6fd94e2114fb94394b921d4f0c901fa6' 
  AND token = '/Uz+v9waqnYcPCjhPVLDCO1SrdL6mCJtP0A1gww6jfs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}