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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8eed722dddfcd167ffac154ff2d0375f9d53f7cd53f43f19eadd2ca3c7f50405' 
  AND token = 'IuPWmqBz+0YlMrlhzJs+v8tg2JBvuQ+6wzQp7NcgeDE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}