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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f2c43bb40921d5e40b0557c233863aecba6ec1bfebf75a3fb0691c2db0dba4c6' 
  AND token = 'amMC4RTrQQNpB2r1R9VJLFmiAe5gmgcO29G3hh5JZNY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}