SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e21ad1bbca0ef60c8c948efb51ef1a314cb5173048f8ae0ae637b47379e33d75' 
  AND token = 'bMOtL+xxZ7aPKIHPUFjAthBm64+rn7cuobCIVMbbmKc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}