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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3749f2c69644fb4b6b910c1dc955878a534b81a266bd6bafb0543aae18516fd8' 
  AND token = '6Gd0wSDhS3Ded9UsIMuyocsUfca8h0vlxoSH8uMVhHA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}