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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b106e6a7ee439efa74cda2b5e13a61a8e38660a20a094fcfc6e432a8c825de46' 
  AND token = '49K1+9hdc1HUYtzwb+TurjJtG3TXUosLH1OizAAKqJE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}