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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '281e4625c033921be523a30f4a620ea79e0b4012d23d0988800a93688a8b2eb2' 
  AND token = 'TPV/gHuQ1e4L/D1bekN/JmNyuWHy80TJ04dmCregmDU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}