SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e079f0f2cad8808d2ff41d07a533e505f7a5f738bee4928a122d2446dad30641' 
  AND token = 'US22Vd4ZiaDLe/ikLXLW+mp0pYtntLgjyI3q61Pb7xQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}