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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0f81bd7e559fa48c5d496bcaa9f1580460a6856e3133af9481c48de3cd78adc4' 
  AND token = 'L4llxLpAqjC8PiC3Erq1lHzJCG5fFPYGIJ4A6fnlVdM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}