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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c5cd424a88d03c882f00a160e72cdd87f04d801cbac38ec80982f0c01e55ff90' 
  AND token = 'JGk+shsjCcSlAMQ6LVH59sbdJbLVOQMZ2h4036mY2Oo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}