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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78140db64016e50f9e50d2746a274091c06c41ef13090ea737fcac8883bb9ba6' 
  AND token = 'CFl43zvcNiWwPeWwswOW8ucWthSfl2tjiz3tXxOerqY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}