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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd4a72217c08322b23e168dc8c7ada8c2621f89b1b9e616b63797416d21809ee2' 
  AND token = '+Ed72CmA0qHm5LoGSSFxfg20s24vZYqKieMZSAtdsG8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}