SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49ee18e0cac18334a4f9b3b45fb6b67ada716358948151c94697e06b5d80c0c0' 
  AND token = '0HJWzy4tQAMWDHz5YzgWLhW0Nqj4NpR6zDnN6VfyXIc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}