SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7221216b0245376eaab50231d164e43bf21cdf3c5032d41e9120ac1f0fa83c92' 
  AND token = '5XkLCZc/IPhYHMzSKpebBO5InUUhocx+3zmZJl3CXEQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}