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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9378936910a6cb0053afccdf8aff0dd2b8c09841cc0389d40f3ede18c65690ed' 
  AND token = 'OO4X6JFRkkwfGnDS5xwOacBltubgHNeMK13UQYs+9QU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}