SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c921ffc1ece262e4d7bc1f1258ec864a570a86402f871dcdab26e944a513cae' 
  AND token = 'D18xTm+swEtiND9H6CMLyTaxfmjtBpy9bDUecGuSmSQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}