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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6103dd22f0f629127544be9a5454baf698050a6d47e013f7028f3e61b770e1f6' 
  AND token = 'YyX+JE1KJ6v5qXc2h7+QcK+hl3nT8ILY8s0F1lRUrd4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}