SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cdc7fd3285e6895289251d7e0ecac41aff04f5035f4d9eac5284d44f91368721' 
  AND token = 'VxdqeI7W2lr1quNM4LSAclGdVAbBYlUBcALZuVTmtPc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}