SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ae3e1ed7dd6b0fdcb891af013d9263bf7efdc1905af644c566e5569d448be8c' 
  AND token = 'M78OxS627Nb9UA8RQbWAGMiuVD7b0MW92nXICmANQTo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}