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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '888c56fdbe714d91ff012541ac24fd6019a3e9bd37b817dc6b1659a2b02134d8' 
  AND token = 'q1Ypy6CqKrrEWPssupso3uSxXIBSyn7xCRWOUYZmpsM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}