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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c950b48cc9ddd504fca96766e9ef110af457a0494306cfcf61b012505137fe0' 
  AND token = 'XxIY5h/KxuwLm1k8QolTPBX4agy9OVtXt+Pb4jzWaBY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}