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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d5fcb5a105689cbbf8626d773f06769e4569c349fb9ea10b5b44df2498adcdc' 
  AND token = '5AyUfVL7Y6TCW7f33l+TjoVK+Nkgh7j0JMtkGpbMrBM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}