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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '724fb03404f68087d266ce4d626c4c1cdb9b2d1aa00561f1c72125535a97cd1f' 
  AND token = 'ISIIZuP9MmHcaz8QbVoiyY0IWgj45JdQ1+HUA29XVJI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00054

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}