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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a636a5130b45899853b86db65ec48bd708853a293086c5605d5017a2486c752' 
  AND token = '++XDgo6PtkwXA+h+sxQVGM+HyLr6dCn5RbWRZQ6EZ6Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}