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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '220ab7a7fada3820b65506c56b40c11ed81a559854ba5b997d6d3bbfdb03bf30' 
  AND token = 'ZE2zsw3sujMR/1GLFS4w0cUxAoPN5Ywt0UmylaUTvBY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}