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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43401b2ed147e7ccfe241553e5f8be60f6ccb3463207db41454394e39ce6aeef' 
  AND token = 'k+ukP+Mr+Am2Smm6VvRbeIKfSZRNg3UYbAlqxtTjeao=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}