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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bbdf3641d07279a93d7abe20111e7bc84ad244bcdaa0dc262f3971d811fca818' 
  AND token = 'YJNwAf8fk3M9+C4gUSFgVGoC3XV0cKAbMzuu4hMzfRM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}