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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e4e48fd5b5635e9f50bfecbc22844e3d943a159a0aaf2ee49517d81757c0787' 
  AND token = 'Cc7yqUKLuSivp5+oSohq1rGAmzYESaZtUQkbu3xSdJk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}