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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cdd03562423fee034e0703b38afca1371713028244ca8366872287efc519a262' 
  AND token = '0WWp3QpxpNF2XIoOoLm4v0sQt/AXgD1dtkHEJCA5rf0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}