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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '882e681e67c4af49a528d8df3bd600ccba7e1f8b3235b4ad2a0bfd21d818ff04' 
  AND token = 'ecfIot/9ZfY7XkL8DFSe8FN/PIZDT1PpWr0y1QtyFgI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}