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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78a3cf64600d3e4b525acae31626169e52348a8f6aa3b825e5e34c41e297a4ed' 
  AND token = 'nuf/URHDXWx1eZTd+s84EmwDJtAKdlIFhMhOCap+Jjo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}