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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '728d5f411b90ba439448652a72e16d273a8d00bceffdb010ae59753a4125a0bf' 
  AND token = '1R2JHpuREZlaHtLz/zINOVFq7EQjoMnbcA0b1CY7tdo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}