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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '378d25260bb99c3bcf9d3957d1e36c9db1c3a4f23807a990daff371a1fac93a3' 
  AND token = 'id3B5Z20kO+pibtmKI9lvx2Bt39a1BQKB98HBHUW6Ow=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}