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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '168c9d100a6c29b2c0defaefa4c7131c45890077c53f64564be44c066c13bd36' 
  AND token = 'AL2+PKMTjjqhxP8nvF7OdAMrLdrTc0v/+2JTqrZj2tU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}