SELECT 
  product_id, 
  feature_id, 
  variant_id 
FROM 
  cscart_product_features_values 
WHERE 
  product_id IN (
    264226, 264884, 264885, 264886, 264887, 
    264888, 264889, 264890, 264891, 264892, 
    264893, 264894, 264895, 264896, 264897
  ) 
  AND feature_id IN (649, 882) 
  AND lang_code = 'en'

Query time 0.00213

JSON explain

{
  "query_block": {
    "select_id": 1,
    "cost_info": {
      "query_cost": "13.08"
    },
    "table": {
      "table_name": "cscart_product_features_values",
      "access_type": "range",
      "possible_keys": [
        "PRIMARY",
        "fl",
        "lang_code",
        "product_id",
        "fpl",
        "idx_product_feature_variant_id"
      ],
      "key": "lang_code",
      "used_key_parts": [
        "lang_code",
        "feature_id",
        "product_id"
      ],
      "key_length": "12",
      "rows_examined_per_scan": 30,
      "rows_produced_per_join": 30,
      "filtered": "100.00",
      "using_index": true,
      "cost_info": {
        "read_cost": "7.08",
        "eval_cost": "6.00",
        "prefix_cost": "13.08",
        "data_read_per_join": "23K"
      },
      "used_columns": [
        "feature_id",
        "product_id",
        "variant_id",
        "lang_code"
      ],
      "attached_condition": "((`webmarco`.`cscart_product_features_values`.`product_id` in (264226,264884,264885,264886,264887,264888,264889,264890,264891,264892,264893,264894,264895,264896,264897)) and (`webmarco`.`cscart_product_features_values`.`feature_id` in (649,882)) and (`webmarco`.`cscart_product_features_values`.`lang_code` = 'en'))"
    }
  }
}