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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1fd278ad86f6711522d906f1c88ac4ce88c7cfe3736793b7c73cc2c688d6def3' 
  AND token = '5Up/CNmDVjfCU+Cq9KZWH8UeIkUxYy38cqOwEfp+2nM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}