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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b0acf3b780aa97e38030929d29923017239e1d8eaded04d0d2f8d694df0fad4' 
  AND token = 'LhX3nRvsKRL0xYg6FKkFHkU3MX2pBpAGXYxoVvfrBj8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}